The Relationship between Drug-Induced Neurogenesis and Pain Behavior in Mice
نویسندگان
چکیده
...................................................................................................................... page 3 Introduction................................................................................................................ page 4 Pain.................................................................................................................. page 4 Mechanisms Involved in Pain Perception and Modulation ............................ page 8 Neurogenesis................................................................................................. page 13 Pharmacological Manipulations of Neurogenesis........................................ page 25 The Current Study ......................................................................................... page 34 Methods .................................................................................................................... page 36 Subjects ......................................................................................................... page 36 Injection Protocol ......................................................................................... page 37 Formalin Test................................................................................................ page 38 Perfusion ....................................................................................................... page 39 Immunohistochemistry .................................................................................. page 40 Microscopy.................................................................................................... page 41 Data Analysis ................................................................................................ page 42 Results....................................................................................................................... page 43 Behavioral Data ............................................................................................ page 43 Neurogenesis Data ........................................................................................ page 45 Discussion................................................................................................................. page 47 Neurogenesis Results..................................................................................... page 47 Behavioral Results......................................................................................... page 49 Implications and Future Directions .............................................................. page 52 Acknowledgements................................................................................................... page 59 References ................................................................................................................ page 59 Tables & Figures...................................................................................................... page 67 The Relationship between Neurogenesis and Pain 3
منابع مشابه
Alterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice
Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...
متن کاملATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. Methods: We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior te...
متن کاملEffect of gossypin on formalin-induced nociceptin in mice
Gossypin is a bioflavonoid isolated from Hibiscus Vitifolus Linn. The antinociception activity of gossypin has been studied in comparison with the standard antinociception agent, morphine, against the experimental model of tonic continuous pain produced by formalin. Formalin (0.1ml of 1% solution) was injected under the plantar surface of right hind paw of mice and the time an animal spent in l...
متن کاملThe role of GABAB receptors in imipramine-induced antinociception in experimental model of neuropathic pain
This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i...
متن کاملبررسی اثر ضددرد استرس به تنهایی یا در حضور آگونیست و آنتاگونیست گیرندههای CCK در درد نوروپاتیک به روش صفحه داغ در موش سوری
Introduction: Recent studies have shown that cold water swimming stress (CWSS) produces analgesia. Although exact mechanism of the analgesia is until unclear, it may attributed to CCK receptors. On the other hand, the effectiveness of analgesic drugs for treatment of neuropathic pain is limited. In the present study, the effects of CCK receptor agonist caerulein and antagonist proglumide , both...
متن کامل